Improvement of Postherpetic Neuralgia After Treatment With Intravenous Acyclovir Followed by Oral Valacyclovir
نویسندگان
چکیده
منابع مشابه
Improvement of postherpetic neuralgia after treatment with intravenous acyclovir followed by oral valacyclovir.
BACKGROUND Postherpetic neuralgia (PHN) is a complication of shingles (herpes zoster), a painful rash due to varicella-zoster virus reactivation. Studies of patients with PHN and zoster sine herpete (radicular pain without rash) support the notion that low-grade viral ganglionitis contributes to pain. If chronic pain reflects active infection, then antiviral therapy may help patients with PHN. ...
متن کاملAcyclovir for treatment of postherpetic neuralgia: efficacy and pharmacokinetics.
Postherpetic neuralgia is the most common complication of herpes zoster (shingles) in the immunocompetent host. Its mechanism is incompletely understood, but one postulate is that continuous replication of varicella-zoster virus (VZV) in nerve tissues may be responsible for the pain. If this is so, antiviral treatment could be advantageous. To test this hypothesis, we performed a randomized, do...
متن کاملPopulation pharmacokinetics of acyclovir in children and young people with malignancy after administration of intravenous acyclovir or oral valacyclovir.
Acyclovir is effective in the prevention and treatment of herpes simplex virus (HSV) and varicella-zoster virus (VZV) infections. The aim of this study was to characterize the population pharmacokinetics of acyclovir observed following treatment with intravenous acyclovir and oral valacyclovir (valaciclovir) in young people with malignancy. Plasma acyclovir concentration-time data were collecte...
متن کاملTreatment of postherpetic neuralgia.
Herpes zoster, a commonly seen condition in daily medical practice, is reported to occur in 10–20% of the population at some time during the lifespan. Chronic, intractable postherpetic neuralgia, a sequela of herpes zoster, presents a clinical challenge. In recent years, effective antiviral agents that can be used in the outpatient setting have been developed for the treatment of herpes zoster ...
متن کاملAcute herpes zoster and postherpetic neuralgia: effects of acyclovir and outcome of treatment with amitriptyline.
This retrospective study was designed to assess the effects of acyclovir treatment of acute herpes zoster on subsequent postherpetic neuralgia, and to examine the effects of amitriptyline in the treatment of postherpetic neuralgia. Eighty seven patients with postherpetic neuralgia of three or more months' duration were studied: 24 of them had had their herpes zoster treated with oral acyclovir....
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2006
ISSN: 0003-9942
DOI: 10.1001/archneur.63.7.noc60049